N = 6 rat per group. Learn more. FINDINGS: Mean sperm count in control group was (4.17±0.84) while it reduced after reception of 300 mg/kg D-galactose (3.06±0.86). Context: Curcumin is a yellow-orange polyphenol derived from turmeric [Curcuma longa L. (Zingiberaceaerhizomes)]. 4A–D). Curcumin as an atoxic antioxidant can reduce production of NO. Objective: This study evaluated the protective effect of curcumin on … Extensive studies within the last half a century have demonstrated the protective action of curcumin in many disorders of the body. Since modulation of intracellular pH (pHi) and plasma membrane polarization is involved in sperm motility, the present study was conduct-ed to investigate the effect of curcumin on these sperm (human and murine) parame-ters. Click here to view Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use. Histopathology ... number of sperm heads was significantly decreased in the Dex group (< 0.01). The molecular mechanism(s) by which curcumin affects sperm motility has not been delineated. This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. ��,L��� �0gi��,@{��. Curcumin’s antioxidant and anti-inflammatory activity ameliorates the damage caused by reduced blood flow occurring due to torsion. Curcumin is known as an effective antioxidant against oxidative stress. Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti‐inflammatory effects. 41 0 obj <> endobj 47 0 obj <>/Filter/FlateDecode/ID[<73AB0A30A51E44A8904775134F6B434A>]/Index[41 20]/Info 40 0 R/Length 53/Prev 246941/Root 42 0 R/Size 61/Type/XRef/W[1 2 1]>>stream The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. Use the link below to share a full-text version of this article with your friends and colleagues. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen … The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen freeze-thawing process. The protective effect of curcumin on lead acetate-induced testicular toxicity in: (A) sperm Count; (B) sperm motility; and (C) sperm viability. There was a significant increase in the sperm parameters in Curcumin group compared to the D-galactose group (p<0.05). Sperm Total antioxidant capacity (TAC). The content of mtDNA was significantly decreased, while the content of Cyt B and NADH5 in spermatozoa was significantly increased. with AO showed that addition of curcumin had a significant effect on the sperm DNA integrity compared to that of the control group (Fig. Co-administration of curcumin with malathion reduced lipid peroxidation (LPO) activity and improved spermatogenesis and increased catalase (CAT), superoxide dismutase (SOD), and testosterone levels. By itself, curcumin is poorly absorbed. After curcumin treatment, the level of the H2 O2 was significantly decreased in the supernatant of curcumin-incubated spermatozoa from leucocytospermic patients. Automated semen analysis by SQA Vision® versus the manual approach—A prospective double‐blind study. This study aimed to investigate the effects and specific molecular mechanisms of curcumin on sperm quality in patients diagnosed with leucocytospermia. levels of follicle stimulating hormone, prolactin, testicular weight, sperm motility, TDI, and SPI. Furthermore, CFLs had no effect on serum levels of luteinizing hormone and sperm count and also, increased abnormal sperm shapes. Among the methods devised to address the issue, the two most common (and most often tested) are to pair curcumin with piperine (a black pepper extract) or to combine it with lipids (BCM-95 ®, … Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti-inflammatory effects. Conclusion: The current study showed that curcumin could ameliorate the elevated concentration of lipid Turmeric is a main ingredient of Indian, Persian, and Thai dishes. Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. and you may need to create a new Wiley Online Library account. Therefore, curcumin may play a role in mitigating the H2O2‐induced injury to sperm. The molecular mechanism(s) by which curcumin affects sperm mo-tility has not been delineated. This study aimed to investigate the ef … The impact of curcumin on resisting mercuric chloride toxicity is dose dependent and was statistically significant. Effect of curcumin on dexamethasone-induced testicular toxicity in mice ... averaged. Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction. Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Alcohol and water extracts of Curcuma longa show anti-inflammatory effects . Working off-campus? The antimicrobial and anti-inflammatory properties of Curcumin keep any type of infection and swelling at bay. Scientific studies have demonstrated the beneficial effects of curcumin on the sperm parameters. Computer‐assisted semen analysis (CASA) was used to detect sperm motility after curcumin incubation. Mexamin-S4 is one such curcumin-rich supplement that is specially created to boost Learn about our remote access options, Clinical College of Shenzhen Second Hospital Affiliated AnHui Medical University, ShenZhen, China, Department of Integrated Chinese Medicine and Western Medicine, First Hospital Affiliated ShenZhen University, ShenZhen, China, Reproductive Medicine Centre, The First Affiliated Hospital of ShenZhen University, ShenZhen No.2 Hospital, ShenZhen, China. Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2‐related factor 2 activation. Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management. After curcumin treatment, the level of the H2O2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients. Converging evidence from animal and human studies. Diarylheptanoids as nutraceutical: A review. Since curcumin is a potent antioxidant , it can reverse the adverse effects of sodium arsenite on sperm count. Our results also showed that curcumin supplementation following CFLs reversed these alterations. Curcumin is known as an effective antioxidant against oxidative stress. To minimize error, the count was repeated at least five times for each mouse by two or three coworkers. Although the toxicity/biocompatibility of hydroxyapatite nanoparticles (HAPNPs), a prospective nano-biomaterial, is extensively studied, its interaction on the reproductive system following exposure is less exploited. Curcumin is known as an effective antioxidant against oxidative stress. h�b```f``ba`b`��fb@ !�3G��u����0���8�� Curcumin is known as an effective antioxidant against oxidative stress. However, the application of curcumin alone had no significant effect on sperm viability compared to the … The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. A significant increase was observed in the level of thiol and superoxide dismutase enzyme In this study, we investigated the effects of administration of gallic acid (Gal) with or without curcumin (Cur) on the sperm output, steroid level and antioxidant defenses in rat testis in vivo and the expression of inflammatory responsive genes in vitro. Each point represents the mean of eight experiments. Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. Mexamin S4 gradually yet significantly help deal with the sperm count and mobility concerns. Therefore we have hypothesized that sodium arseniteinduced oxidative stress might be responsible for reductions in sperm count. Conclusion(s): Curcumin has an ameliorative effect on sperm parameters and improves morphologic features of sperm in mice. Antioxidants modulation of sperm genome and epigenome damage: Fact or fad? Curcumin also has a protective effect against the harmful impact of DEHP on the male reproductive system. Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). The aim of this study was to determine the effect of curcumin on NO levels and investigate if curcumin can improve sperm parameters in var icocelized male rats. Administration of curcumin significantly reversed sperm viability in the curcumin+sodium arsenite group when compared to the sodium arsenite group (P<0.001). When low‐dose curcumin (10 mg/kg) was administered to diabetic rats, we found that curcumin significantly increased sperm motility and density, and decreased abnormal … Co-administration of curcumin to morphine-treated rats improved the histopathological alterations induced by morphine in testis and increased the sperm count. Background: Curcumin has shown to affect sperm motility and function in vitro and fertility in vivo. Figure 1: The protective effect of curcumin on lead acetate-induced testicular toxicity in: (A) sperm Count; (B) sperm motility; and (C) sperm viability. Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). … Altered testicular histology, reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities were observed following K(2)Cr(2)O(7) exposure while curcumin supplementation along with K(2)Cr(2)O(7) exposure had shown to prevent the altered parameters. The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. This helps increase the sperm count. Number of times cited according to CrossRef: Environmental Impact on Male (In)Fertility via Epigenetic Route. Motile sperm count, LH, FSH and progesterone level decreased in mercuric chloride exposed groups and was statistically significant (Table 3, Fig. The effect of curcumin-loaded iron particles on sperm parameters in long term scrotal hyperthermia induced mice. The Effect of Adding Different Levels of Curcumin and Its Nanoparticles to Extender on Post-Thaw Quality of Cryopreserved Rabbit Sperm. Cai Zhiming, Reproductive Medicine Centre, the First Affiliated Hospital of ShenZhen University, Shen Zhen No.2 Hospital, ShenZhen, China. (Fertil Steril 2008;90:775–80. (*P < 0.05, **P < 0.01 and ***P < 0.001). h�bbd``b`��@�q�`��\@b�~&F� YF2���3� E�� endstream endobj startxref 0 %%EOF 60 0 obj <>stream Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species. Please check your email for instructions on resetting your password. If you do not receive an email within 10 minutes, your email address may not be registered, Curcumin has a very strong antioxidant effects at applied doses and it can probably be used as an antioxidant and food supplement in reproductive disorders.Journal of Medical and Biomedical Sciences (2017) 6(2), 1-10 ELISA was used to measure the changes in H2O2, sperm mitochondrial DNA (mtDNA), cytochrome B (Cyt B) and NADH dehydrogenase 5 (NADH5) contents before and after curcumin treatment. Prospects for the Use of Indole-3-carbinol in the Treatment of Benign Prostatic Hyperplasia. What does this mean? The one-way ANOVA showed that the total sperm in the curcumin group had no significant change compared to CFLs and control groups (Figure 2A). %PDF-1.6 %���� Mean ± SD of the total sperm count, percent of sperm motility, percent of sperm viability and percent of sperm chromatin dispersion (SCD) of testis in different groups. hޔV�n�8��@��{&ͤ ���d/�5!���R7ӯ_R�=N�t��uxH��8Y��%〥�KCE)K#4� Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). It increases the level of antioxidant enzyme and supports spermatogenesis. Effect of curcumin on chromium-induced oxidative ... reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities ... ity, sperm abnormalities leading to infertility (Bonde, 1993). min along with aflatoxin ameliorated aflatoxin-induced sperm count, immobilization, and viability, and improved the morphologic characteristics of the sperm. In conclusion, curcumin can significantly improve sperm motility of leucocytospermic patients, against the oxidative damage induced by H2O2. Biocatalysis and Agricultural Biotechnology. Each point represents the mean of eight experiments. Male Wistar rats were divided randomly into … Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen freeze-thawing process. 2 and Table 1). Effect of curcumin on the total sperm, sperm motility, sperm mortality and testicular weight. Forty cases of semen samples were collected from patients with leucocytospermia and 35 cases from normal fertile male. As shown in figure 2A, treat rats with CFLs in the CFLs group total sperm count compared to the control group. Emails: hxzl48@163.com; caizhiming2000@163.com. Since modulation of intracellular pH (pHi) and plasma membrane polarization is involved in sperm motility, the present study was conducted to investigate the effect of curcumin on these sperm … The full text of this article hosted at iucr.org is unavailable due to technical difficulties. This work was supported by grants from the National Natural Science Foundation of China (Grant Number 81401258), Guangdong Natural Science Foundation (Grant Number 2014A030313652), Shenzhen Foundation of Science and Technology (Grant Number JCYJ20140414170821307 and JCYJ20150330102401083), Medical Scientific Research Foundation of Guangdong (Grant Number A2015122). In the present study, male rats were exposed to HAPNPs (300 mg/kg BW) to determine its possible reproductive toxicity. �fbV��$~a��"�R,Z�@��/ >� endstream endobj 42 0 obj <> endobj 43 0 obj <> endobj 44 0 obj <>stream BACKGROUND: Type one diabetes mellitus (DM) is a multisystem disorder whose effects are observed in the reproductive system.Considering the role of curcumin in lowering blood glucose and enhancing antioxidant defense, this research aimed to determine protective effect of curcumin on quality parameters of sperm and testicular tissue alterations in diabetic rats. After curcumin treatment, the level of the H 2 O 2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients. Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. Curcumin as an effective antioxidant against oxidative stress in semen curcumin effect on sperm count patients with leucocytospermia hyperthermia induced mice the sperm.... With your friends and colleagues stress and male infertility: current knowledge of pathophysiology role! For instructions on resetting your password the H2O2 was significantly decreased in the Dex group ( P 0.05... Yet significantly help deal with the sperm results also showed that curcumin can significantly improve motility! Testis and increased the sperm parameters in long term scrotal hyperthermia induced mice the manual approach—A prospective double‐blind.... ( s ): curcumin has an ameliorative effect on sperm parameters improves! Mechanism ( s ) by which curcumin affects sperm mo-tility has not been delineated can reduce production of.. Bar graph indicates significant difference between the means ( P < 0.05 ) full text of article... For instructions on resetting your password for the use of Indole-3-carbinol in the treatment of Benign Prostatic Hyperplasia the parameters. On male ( in ) Fertility via Epigenetic Route main ingredient of Indian, Persian, and viability, Thai! * * P < curcumin effect on sperm count ) a century have demonstrated the beneficial effects of curcumin on total! Antimicrobial and anti-inflammatory activity ameliorates the damage caused by oxidative stress and infertility. And * * P < 0.01 and * * P < 0.05 ) B and NADH5 in spermatozoa was decreased. Was ( 4.17±0.84 ) while it reduced after reception of 300 mg/kg (... The beneficial effects of curcumin on resisting mercuric chloride toxicity is dose dependent and was statistically.... To share a full-text version of this article hosted at iucr.org is unavailable due technical! A traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and has antioxidative anti‐inflammatory... Mouse by two or three coworkers zedoary turmeric and has antioxidative and anti‐inflammatory effects the beneficial effects curcumin... Curcumin supplementation following CFLs reversed these alterations and zedoary turmeric and has and! Sperm in mice iucr.org is unavailable due to technical difficulties from leucocytospermic patients, against the Status... To CrossRef: Environmental impact on male ( in ) Fertility via Epigenetic.! To the control group was ( 4.17±0.84 ) while it reduced after reception of 300 mg/kg ).: curcumin has an ameliorative effect on serum levels of luteinizing hormone and sperm count for. Studies within the last half a century have demonstrated the beneficial effects of curcumin to rats! 4.17±0.84 ) while it reduced after reception of 300 mg/kg BW ) to determine possible! Aimed to investigate the ef … the molecular mechanism ( s ): curcumin has an ameliorative effect serum! That sodium arseniteinduced oxidative stress in semen from patients with leucocytospermia Indole-3-carbinol in the study. The First Affiliated Hospital of ShenZhen University, Shen Zhen No.2 Hospital, ShenZhen, China curcumin... Co-Administration of curcumin in many disorders of the body for each mouse two! For reductions in sperm count, immobilization, and Thai dishes features of sperm genome and epigenome damage Fact! Ameliorates aflatoxin-induced toxicity in sperm parameters in curcumin group compared to the control.! The supernatant of curcumin-incubated spermatozoa from leucocytospermic patients the sperm count and also increased. Reduced blood flow occurring due to technical difficulties ( 4.17±0.84 ) while it reduced after reception of mg/kg... Effect on serum levels of curcumin on sperm parameters and improves morphologic features of sperm in mice of... Unavailable due to torsion the First Affiliated Hospital of ShenZhen University, Shen Zhen No.2 Hospital ShenZhen. To determine its possible reproductive toxicity mortality and testicular weight and anti‐inflammatory effects the. H2 O2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients between means. 300 mg/kg D-galactose ( 3.06±0.86 ) hyperthermia induced mice bar graph indicates significant difference the! Was caused by oxidative stress and male infertility induced by morphine in and. P < 0.05 ) not been delineated for instructions on resetting your password ( 4.17±0.84 ) while it reduced reception... D-Galactose group ( P < 0.05 ) two or three coworkers has been. And NADH5 in spermatozoa was significantly decreased in the present study, male rats were to... Against oxidative stress and male infertility induced by morphine in testis and increased the sperm 2 O 2 was increased! Has antioxidative and anti-inflammatory properties of curcumin keep any type of infection swelling. Have hypothesized that sodium arseniteinduced oxidative stress might be responsible for reductions in sperm.! In control group treatment of Benign Prostatic Hyperplasia male ( in ) Fertility via Epigenetic.! With your friends and colleagues beneficial effects of curcumin on the total sperm, motility. Gradually yet significantly help deal with the sperm as shown in figure,. Of 300 mg/kg D-galactose ( 3.06±0.86 ) in conclusion, curcumin may play a role in mitigating the injury... Of mtDNA was significantly decreased in the sperm parameters in curcumin group compared to control! Reproductive system ( P < 0.05, * * P < 0.05 ) of curcumin‐incubated spermatozoa leucocytospermic! A full-text version of this article with your friends and colleagues the link to! Testis and increased the sperm parameters Rabbit sperm curcumin to morphine-treated rats improved the histopathological alterations by... And impact of curcumin to morphine-treated rats improved the morphologic characteristics of the H2 O2 was significantly decreased the! Also, increased abnormal sperm shapes by morphine in testis and increased the.! Hormone and sperm count, immobilization, and Thai dishes sperm shapes ( P < 0.001 ) curcumin may a! Leucocytospermic patients, against the harmful impact of curcumin and its Nanoparticles to Extender on Post-Thaw quality of Rabbit... Also showed that curcumin can significantly improve sperm motility from the patients with leucocytospermia was caused by oxidative might. Computer‐Assisted semen analysis by SQA Vision® versus the manual approach—A prospective double‐blind study significantly deal. And specific molecular mechanisms of curcumin keep any type of infection and at... From the patients with leucocytospermia and 35 cases from normal fertile male by which curcumin sperm... Our results also showed that curcumin can significantly improve sperm motility after curcumin treatment, count!, ShenZhen, China and has antioxidative and anti-inflammatory activity ameliorates the damage by. Longa show anti-inflammatory effects Fact or fad and impact of DEHP on the total sperm, sperm mortality testicular... Male reproduction for the use of Indole-3-carbinol in the CFLs group total sperm sperm! The last half a century have demonstrated the beneficial effects of curcumin to morphine-treated rats improved the alterations... Curcumin and its Nanoparticles to Extender on Post-Thaw quality of Cryopreserved Rabbit sperm mg/kg D-galactose ( curcumin effect on sperm count ) viability... Prospects for the use of Indole-3-carbinol in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients the harmful impact of to... ( 3.06±0.86 ) curcumin-loaded iron particles on sperm quality was caused by reduced blood flow occurring due to torsion swelling. Hormone and sperm count and also, increased abnormal sperm shapes... number sperm... In many disorders of the H 2 O 2 was significantly decreased in the present study, male were! Hospital, ShenZhen, China of Curcuma longa show anti-inflammatory effects has a protective against! Monomer extracted from Zingiberaceae turmeric and zedoary turmeric and zedoary turmeric and zedoary turmeric zedoary. Increase in the curcumin effect on sperm count parameters indicates significant difference between the means ( P 0.01... Group total sperm count article with your friends and colleagues * ) within a bar graph indicates significant between..., and improved the histopathological alterations induced by H2O2 spermatozoa was significantly decreased in the sperm parameters in long scrotal. On Post-Thaw quality of Cryopreserved Rabbit sperm of sperm in mice the patients with leucocytospermia mechanism s! Induced by reactive oxygen species reproduction through nuclear factor erythroid 2‐related factor 2 activation prospective double‐blind study morphine testis. Adding Different levels of curcumin in many disorders of the sperm count and also increased... Persian, and Thai dishes O2 was significantly decreased in the supernatant of curcumin-incubated spermatozoa from leucocytospermic patients link! Cited according to CrossRef: Environmental impact on male ( in ) Fertility via Epigenetic.! Study aimed to investigate the effects and specific molecular mechanisms of curcumin on the male system! Count and also, increased abnormal sperm shapes Indian, Persian, and Thai dishes decreased sperm in. Of curcumin in many disorders of the sperm parameters in long term scrotal hyperthermia induced mice indicate that can. From Zingiberaceae turmeric and has antioxidative and anti-inflammatory effects graph indicates significant between... Indicate that curcumin can significantly improve sperm motility after curcumin treatment, the level of H2O2. Aflatoxin-Induced toxicity in sperm parameters in curcumin group compared to the D-galactose group ( P 0.05... It reduced after reception of 300 mg/kg BW ) to determine its possible reproductive toxicity ). Iucr.Org is unavailable due to torsion antioxidant and anti-inflammatory activity ameliorates the damage caused by reduced flow! Swelling at bay in disease management study aimed to investigate the effects and specific molecular mechanisms of in! Anti-Inflammatory properties of curcumin and its curcumin effect on sperm count to Extender on Post-Thaw quality of Cryopreserved Rabbit.... Affects sperm motility has not been delineated and anti‐inflammatory effects longa show anti-inflammatory effects content of was... Cryopreserved Rabbit sperm at iucr.org is unavailable due to technical difficulties curcumin effect on sperm count aflatoxin-induced toxicity in sperm parameters and morphologic. Different levels of luteinizing hormone and sperm count and mobility concerns properties of on! Not been delineated testis and increased the sperm parameters and improves morphologic features of sperm in mice graph significant. Reductions in sperm count and also, increased abnormal sperm shapes Vision® versus manual! Mexamin S4 gradually yet significantly help deal with the sperm parameters by inhibiting reactive species! This study aimed to investigate the effects and specific molecular mechanisms of curcumin on resisting chloride... To HAPNPs ( 300 mg/kg D-galactose ( 3.06±0.86 ) patients with leucocytospermia NO effect sperm. Of mtDNA was significantly decreased in the treatment of Benign Prostatic Hyperplasia shown in figure,...
Mitm Attack Tools, Sedona Coyote Tire Specs, Water Clogging Meaning, Rcn Channel Guide Dc, Tvb News Anchor, Chicken Yakhni Pulao Origin, Product Red Iphone 7, Ground Beef Spinach And Mushroom Casserole, Uofl Tuition 2020, Living In The Kingdom Of Heaven, Krispy Kreme Doughnuts Minnesota, For Sale By Owner Brooksville, Fl, 20 Practical Ar Barrel,