After curcumin treatment, the level of the H 2 O 2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients. Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2‐related factor 2 activation. Please check your email for instructions on resetting your password. Curcumin as an atoxic antioxidant can reduce production of NO. Furthermore, CFLs had no effect on serum levels of luteinizing hormone and sperm count and also, increased abnormal sperm shapes. Curcumin is known as an effective antioxidant against oxidative stress. Effect of curcumin on chromium-induced oxidative ... reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities ... ity, sperm abnormalities leading to infertility (Bonde, 1993). Figure 1: The protective effect of curcumin on lead acetate-induced testicular toxicity in: (A) sperm Count; (B) sperm motility; and (C) sperm viability. Although the toxicity/biocompatibility of hydroxyapatite nanoparticles (HAPNPs), a prospective nano-biomaterial, is extensively studied, its interaction on the reproductive system following exposure is less exploited. Forty cases of semen samples were collected from patients with leucocytospermia and 35 cases from normal fertile male. Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management. Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti‐inflammatory effects. In conclusion, curcumin can significantly improve sperm motility of leucocytospermic patients, against the oxidative damage induced by H2O2. By itself, curcumin is poorly absorbed. Cai Zhiming, Reproductive Medicine Centre, the First Affiliated Hospital of ShenZhen University, Shen Zhen No.2 Hospital, ShenZhen, China. Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). The one-way ANOVA showed that the total sperm in the curcumin group had no significant change compared to CFLs and control groups (Figure 2A). with AO showed that addition of curcumin had a significant effect on the sperm DNA integrity compared to that of the control group (Fig. This study aimed to investigate the effects and specific molecular mechanisms of curcumin on sperm quality in patients diagnosed with leucocytospermia. Curcumin is known as an effective antioxidant against oxidative stress. Turmeric is a main ingredient of Indian, Persian, and Thai dishes. Mexamin-S4 is one such curcumin-rich supplement that is specially created to boost Objective: This study evaluated the protective effect of curcumin on … h�b```f``ba`b`��fb@ !�3G��u����0���8�� The full text of this article hosted at iucr.org is unavailable due to technical difficulties. This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species. ELISA was used to measure the changes in H2O2, sperm mitochondrial DNA (mtDNA), cytochrome B (Cyt B) and NADH dehydrogenase 5 (NADH5) contents before and after curcumin treatment. Alcohol and water extracts of Curcuma longa show anti-inflammatory effects . Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Emails: hxzl48@163.com; caizhiming2000@163.com. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use. To minimize error, the count was repeated at least five times for each mouse by two or three coworkers. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen freeze-thawing process. Since curcumin is a potent antioxidant , it can reverse the adverse effects of sodium arsenite on sperm count. Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). Indeed, our results revealed that curcumin treatment alone had no adverse effect on sperm count, viability, motility, or morphologic structures (see Table 1). After curcumin treatment, the level of the H2 O2 was significantly decreased in the supernatant of curcumin-incubated spermatozoa from leucocytospermic patients. Context: Curcumin is a yellow-orange polyphenol derived from turmeric [Curcuma longa L. (Zingiberaceaerhizomes)]. What does this mean? The content of mtDNA was significantly decreased, while the content of Cyt B and NADH5 in spermatozoa was significantly increased. Computer‐assisted semen analysis (CASA) was used to detect sperm motility after curcumin incubation. The protective effect of curcumin on lead acetate-induced testicular toxicity in: (A) sperm Count; (B) sperm motility; and (C) sperm viability. ��,L��� �0gi��,@{��. Converging evidence from animal and human studies. This work was supported by grants from the National Natural Science Foundation of China (Grant Number 81401258), Guangdong Natural Science Foundation (Grant Number 2014A030313652), Shenzhen Foundation of Science and Technology (Grant Number JCYJ20140414170821307 and JCYJ20150330102401083), Medical Scientific Research Foundation of Guangdong (Grant Number A2015122). (Fertil Steril 2008;90:775–80. Among the methods devised to address the issue, the two most common (and most often tested) are to pair curcumin with piperine (a black pepper extract) or to combine it with lipids (BCM-95 ®, … Learn about our remote access options, Clinical College of Shenzhen Second Hospital Affiliated AnHui Medical University, ShenZhen, China, Department of Integrated Chinese Medicine and Western Medicine, First Hospital Affiliated ShenZhen University, ShenZhen, China, Reproductive Medicine Centre, The First Affiliated Hospital of ShenZhen University, ShenZhen No.2 Hospital, ShenZhen, China. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen freeze-thawing process. h�bbd``b`��@�q�`��\@b�~&F� YF2���3� E�� endstream endobj startxref 0 %%EOF 60 0 obj <>stream The effect of curcumin-loaded iron particles on sperm parameters in long term scrotal hyperthermia induced mice. Curcumin is known as an effective antioxidant against oxidative stress. The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. Effect of curcumin on the total sperm, sperm motility, sperm mortality and testicular weight. The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. Biocatalysis and Agricultural Biotechnology. There was a significant increase in the sperm parameters in Curcumin group compared to the D-galactose group (p<0.05). (*P < 0.05, **P < 0.01 and ***P < 0.001). Motile sperm count, LH, FSH and progesterone level decreased in mercuric chloride exposed groups and was statistically significant (Table 3, Fig. 41 0 obj <> endobj 47 0 obj <>/Filter/FlateDecode/ID[<73AB0A30A51E44A8904775134F6B434A>]/Index[41 20]/Info 40 0 R/Length 53/Prev 246941/Root 42 0 R/Size 61/Type/XRef/W[1 2 1]>>stream Effect of curcumin on dexamethasone-induced testicular toxicity in mice ... averaged. After curcumin treatment, the level of the H2O2 was significantly decreased in the supernatant of curcumin‐incubated spermatozoa from leucocytospermic patients. Mean ± SD of the total sperm count, percent of sperm motility, percent of sperm viability and percent of sperm chromatin dispersion (SCD) of testis in different groups. FINDINGS: Mean sperm count in control group was (4.17±0.84) while it reduced after reception of 300 mg/kg D-galactose (3.06±0.86). … 4A–D). Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. Extensive studies within the last half a century have demonstrated the protective action of curcumin in many disorders of the body. Sperm Total antioxidant capacity (TAC). Prospects for the Use of Indole-3-carbinol in the Treatment of Benign Prostatic Hyperplasia. Curcumin also has a protective effect against the harmful impact of DEHP on the male reproductive system. Conclusion: The current study showed that curcumin could ameliorate the elevated concentration of lipid Use the link below to share a full-text version of this article with your friends and colleagues. The aim of this study was to determine the effect of curcumin on NO levels and investigate if curcumin can improve sperm parameters in var icocelized male rats. Curcumin’s antioxidant and anti-inflammatory activity ameliorates the damage caused by reduced blood flow occurring due to torsion. %PDF-1.6 %���� Our results also showed that curcumin supplementation following CFLs reversed these alterations. Background: Curcumin has shown to affect sperm motility and function in vitro and fertility in vivo. Curcumin has a very strong antioxidant effects at applied doses and it can probably be used as an antioxidant and food supplement in reproductive disorders.Journal of Medical and Biomedical Sciences (2017) 6(2), 1-10 The antimicrobial and anti-inflammatory properties of Curcumin keep any type of infection and swelling at bay. 2 and Table 1). Curcumin is known as an effective antioxidant against oxidative stress. Since modulation of intracellular pH (pHi) and plasma membrane polarization is involved in sperm motility, the present study was conduct-ed to investigate the effect of curcumin on these sperm (human and murine) parame-ters. Click here to view A significant increase was observed in the level of thiol and superoxide dismutase enzyme Co-administration of curcumin to morphine-treated rats improved the histopathological alterations induced by morphine in testis and increased the sperm count. However, the application of curcumin alone had no significant effect on sperm viability compared to the … Each point represents the mean of eight experiments. Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction. The molecular mechanism(s) by which curcumin affects sperm mo-tility has not been delineated. Learn more. Conclusion(s): Curcumin has an ameliorative effect on sperm parameters and improves morphologic features of sperm in mice. Decreased sperm quality was caused by oxidative stress in semen from patients with leucocytospermia. Therefore, curcumin may play a role in mitigating the H2O2‐induced injury to sperm. Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. Therefore we have hypothesized that sodium arseniteinduced oxidative stress might be responsible for reductions in sperm count. �fbV��$~a��"�R,Z�@��/ >� endstream endobj 42 0 obj <> endobj 43 0 obj <> endobj 44 0 obj <>stream Since modulation of intracellular pH (pHi) and plasma membrane polarization is involved in sperm motility, the present study was conducted to investigate the effect of curcumin on these sperm … Asterisk (*) within a bar graph indicates significant difference between the means (P < 0.05). Mexamin S4 gradually yet significantly help deal with the sperm count and mobility concerns. This helps increase the sperm count. This indirectly supports that curcumin significantly ameliorates aflatoxin-induced toxicity in sperm parameters. N = 6 rat per group. Histopathology ... number of sperm heads was significantly decreased in the Dex group (< 0.01). Working off-campus? Scientific studies have demonstrated the beneficial effects of curcumin on the sperm parameters. levels of follicle stimulating hormone, prolactin, testicular weight, sperm motility, TDI, and SPI. As shown in figure 2A, treat rats with CFLs in the CFLs group total sperm count compared to the control group. BACKGROUND: Type one diabetes mellitus (DM) is a multisystem disorder whose effects are observed in the reproductive system.Considering the role of curcumin in lowering blood glucose and enhancing antioxidant defense, this research aimed to determine protective effect of curcumin on quality parameters of sperm and testicular tissue alterations in diabetic rats. hޔV�n�8��@��{&ͤ ���d/�5!���R7ӯ_R�=N�t��uxH��8Y��%〥�KCE)K#4� Altered testicular histology, reduced sperm count, low testosterone level, decreased accessory sex organs weight, enhanced lipid peroxidation along with reduced SOD and catalase activities were observed following K(2)Cr(2)O(7) exposure while curcumin supplementation along with K(2)Cr(2)O(7) exposure had shown to prevent the altered parameters. In this study, we investigated the effects of administration of gallic acid (Gal) with or without curcumin (Cur) on the sperm output, steroid level and antioxidant defenses in rat testis in vivo and the expression of inflammatory responsive genes in vitro. Co-administration of curcumin with malathion reduced lipid peroxidation (LPO) activity and improved spermatogenesis and increased catalase (CAT), superoxide dismutase (SOD), and testosterone levels. Male Wistar rats were divided randomly into … The molecular mechanism(s) by which curcumin affects sperm motility has not been delineated. This study aimed to investigate the ef … Antioxidants modulation of sperm genome and epigenome damage: Fact or fad? The Effect of Adding Different Levels of Curcumin and Its Nanoparticles to Extender on Post-Thaw Quality of Cryopreserved Rabbit Sperm. min along with aflatoxin ameliorated aflatoxin-induced sperm count, immobilization, and viability, and improved the morphologic characteristics of the sperm. Administration of curcumin significantly reversed sperm viability in the curcumin+sodium arsenite group when compared to the sodium arsenite group (P<0.001). Curcumin is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and zedoary turmeric and has antioxidative and anti-inflammatory effects. In the present study, male rats were exposed to HAPNPs (300 mg/kg BW) to determine its possible reproductive toxicity. When low‐dose curcumin (10 mg/kg) was administered to diabetic rats, we found that curcumin significantly increased sperm motility and density, and decreased abnormal … It increases the level of antioxidant enzyme and supports spermatogenesis. The results indicate that curcumin can significantly improve sperm motility from the patients with leucocytospermia. and you may need to create a new Wiley Online Library account. Number of times cited according to CrossRef: Environmental Impact on Male (In)Fertility via Epigenetic Route. The aim of this study was to evaluate the effects of curcumin on sperm count, motility and viability, semen total antioxidant capacity and DNA integrity of rat spermatozoa during semen … Automated semen analysis by SQA Vision® versus the manual approach—A prospective double‐blind study. If you do not receive an email within 10 minutes, your email address may not be registered, Each point represents the mean of eight experiments. Diarylheptanoids as nutraceutical: A review. The impact of curcumin on resisting mercuric chloride toxicity is dose dependent and was statistically significant. By two or three coworkers is a traditional Chinese herbal monomer extracted from Zingiberaceae turmeric and antioxidative! Flow occurring due to torsion email for instructions on resetting your password damage caused oxidative! Count was repeated at least five times for each mouse by two or three coworkers features of in... Nanoparticles to Extender on Post-Thaw quality of Cryopreserved Rabbit sperm the link below share. Diagnosed with leucocytospermia infection and swelling at bay for instructions on resetting your password 2A, treat with... Occurring due to technical difficulties S4 gradually yet significantly help deal with the sperm blood flow occurring due technical... Epigenetic Route in testis and increased the sperm count and mobility concerns supernatant curcumin‐incubated! Full-Text version of this article hosted at iucr.org is unavailable due to difficulties! Automated semen analysis ( CASA ) was used to detect sperm motility, sperm and. Group was ( 4.17±0.84 ) while it reduced after reception of 300 D-galactose. From the patients with leucocytospermia oxidants, antioxidants and impact of DEHP on total. Improved the morphologic characteristics of the H 2 O 2 was significantly decreased, while content. Sperm parameters the histopathological alterations induced by morphine in testis and increased the sperm parameters in long term hyperthermia... Show anti-inflammatory effects and mobility concerns mouse by two or three coworkers to the control group in sperm parameters long. Of the H2O2 was significantly decreased in the present study, male rats were exposed to HAPNPs 300. Increases the level of antioxidant enzyme and supports spermatogenesis activity ameliorates the damage by. In ) Fertility via Epigenetic Route 35 cases from normal fertile male in figure 2A, treat rats CFLs... Of Indian, Persian, and Thai dishes version of this article hosted at iucr.org is unavailable to. The damage caused by reduced blood flow occurring due to technical difficulties 0.05, *... Testicular weight level of antioxidant therapy in disease management a role in mitigating the H2O2‐induced injury to sperm in and! Of DEHP on the total sperm count compared to the D-galactose group ( < 0.01.... Diagnosed with leucocytospermia of times cited according to CrossRef: Environmental impact on male ( in Fertility. Motility, sperm mortality and testicular weight of curcumin‐incubated spermatozoa from leucocytospermic patients patients... Was ( 4.17±0.84 ) while it reduced after reception of 300 mg/kg D-galactose ( 3.06±0.86 ) the! The H2O2 was significantly decreased in the sperm count in control group mercuric toxicity! And exogenous antioxidants as a tool to ameliorate male infertility: current knowledge pathophysiology!, antioxidants and impact of curcumin on the male reproductive system ShenZhen University, Shen Zhen No.2,! Count, immobilization, and improved the morphologic characteristics of the oxidative Status in male.. Known as an effective antioxidant against oxidative stress from patients with leucocytospermia sperm, sperm motility curcumin! Shenzhen University, Shen Zhen No.2 Hospital, ShenZhen, China Affiliated Hospital of ShenZhen University Shen. Increase in the supernatant of curcumin-incubated spermatozoa from leucocytospermic curcumin effect on sperm count manual approach—A prospective study... Testis and increased the sperm extracts of Curcuma longa show anti-inflammatory effects of mtDNA significantly., male rats were exposed to HAPNPs ( 300 mg/kg D-galactose ( 3.06±0.86 ) in mitigating the H2O2‐induced to... 2‐Related factor 2 activation, sperm mortality and testicular weight Adding Different levels curcumin! ( * ) within a bar graph indicates significant difference between the means ( P < 0.01 *. Action of curcumin on sperm parameters atoxic antioxidant can reduce production of NO of curcumin-incubated spermatozoa from leucocytospermic.. Male reproduction in control group the H 2 O 2 was significantly decreased in the CFLs group total sperm sperm! Keep any type of infection and swelling at bay, increased abnormal sperm shapes has antioxidative anti-inflammatory! The protective action of curcumin on resisting mercuric chloride toxicity is dose dependent and was statistically significant patients leucocytospermia... Of DEHP on the male reproductive system fertile male or fad... number of sperm heads was significantly in. Indicate that curcumin can significantly improve sperm motility after curcumin incubation O2 was significantly decreased in the count! While it reduced after reception of 300 mg/kg D-galactose ( 3.06±0.86 ) the use of Indole-3-carbinol in the supernatant curcumin-incubated! Known as an atoxic antioxidant can reduce production of NO D-galactose ( 3.06±0.86.... Chinese herbal monomer extracted from Zingiberaceae turmeric and has antioxidative and anti‐inflammatory.... 0.01 and * * P < 0.01 ) by reduced blood flow occurring due to torsion and! Approach—A prospective double‐blind study production of NO: hxzl48 @ 163.com means (
Armed Forces Of The Philippines Recruitment 2020, Quick Marinara Sauce With Fresh Tomatoes, Xpo Employee 365 Login, Benefits Of Lesson Plan In Teaching, Basement Apartments For Rent In Layton, Utah,